Terminal Modifiers / Phosphoramidites
Reverse Abasic Phosphoramidite
Quick view. A reverse-orientation dSpacer phosphoramidite with 3'-O-DMTr and a 5'-CE phosphoramidite group for introducing an inverted non-nucleobasic spacer in research-use oligonucleotides. CAS 401813-16-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | plozasiran |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Related product programs
Product profile
Reverse Abasic Phosphoramidite is classified as terminal modifiers / phosphoramidites (Formula C35H45N2O6P; molecular weight 620.70).
Reverse Abasic Phosphoramidite — Introduction of an inverted non-nucleobasic dSpacer residue during standard 3'-to-5' research-use oligonucleotide synthesis.
For Reverse Abasic Phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- Reverse abasic amidite
- dSpacer-5'-CE Phosphoramidite
- dSpacer Reverse CE Phosphoramidite
Useful catalog search terms
- 401813-16-9
- PubChem CID 10189291
- PA055
Physicochemical data
| PubChem CID | 10189291 |
|---|---|
| InChIKey | WPNQXLQBMSUHFX-JUWSMZLESA-N |
| SMILES | COc1ccc(C(O[C@H]2CCO[C@@H]2COP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
| InChI | InChI=1S/C35H45N2O6P/c1-26(2)37(27(3)4)44(41-23-10-22-36)42-25-34-33(21-24-40-34)43-35(28-11-8-7-9-12-28,29-13-17-31(38-5)18-14-29)30-15-19-32(39-6)20-16-30/h7-9,11-20,26-27,33-34H,10,21,23-25H2,1-6H3/t33-,34+,44?/m0/s1 |
| Sugar motif | 1',2'-dideoxyribose |
| 3'-O group | DMTr |
| 5'-O group | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| Orientation | Reverse 3'-O-DMTr / 5'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite
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OR-RP-00073'-O-DMTr-2'-dG(dmf)-5'-CE-Phosphoramidite
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OR-RP-00083'-O-DMTr-2'-dT-5'-CE-Phosphoramidite
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OR-RP-0011N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite
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OR-RP-00133'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite
Reverse Phosphoramidites · CAS: 1309448-27-8
Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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