DNA / Phosphoramidites
N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite
Quick view. A reverse-orientation N6-benzoyl-2'-deoxyadenosine phosphoramidite bearing a 3'-DMTr group and a 5'-cyanoethyl N,N-diisopropylphosphoramidite group. CAS 140712-82-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | onvuzosiran |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Product profile
N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite is classified as dna / phosphoramidites (Formula C47H52N7O7P; molecular weight 857.95).
N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite — Identity-defined dA(Bz) reverse amidite for research workflows involving 5'-to-3' incorporation of deoxyadenosine within synthetic oligonucleotides.
For N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- dA(Bz)-CE reverse phosphoramidite
- dA(Bz)-5'-CE phosphoramidite
- DMT-dA(Bz)-CE inverted phosphoramidite
- N6-benzoyl-3'-O-DMTr-dA-5'-CE phosphoramidite
Useful catalog search terms
- CAS 140712-82-9
Physicochemical data
| Nucleoside | 2'-Deoxyadenosine |
|---|---|
| Base protection | N6-Benzoyl |
| 3' protection | DMTr |
| 5'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| Synthesis orientation | Reverse 5'-to-3' |
| PubChem CID | 17998961 |
| InChIKey | JMABKCCHUAJFJE-AKWFTNRHSA-N |
| InChI | InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(58-27-13-26-48)59-29-41-40(28-42(60-41)53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)61-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H](C[C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H](C[C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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