2′-OMe / Phosphoramidites
3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite
Quick view. A reverse-orientation 2'-O-methyluridine phosphoramidite with 3'-O-DMTr and a 5'-CE phosphoramidite group for research-use oligonucleotide synthesis. CAS 2721427-32-1. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | onvuzosiran |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Related product programs
Product profile
3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite is classified as 2′-ome / phosphoramidites (Formula C40H49N4O9P; molecular weight 760.82).
3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite — Reverse-orientation 2'-O-methyluridine building block for research-use oligonucleotide synthesis.
For 3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-DMT-2'-OMe-U-CE Reverse
- 2'-O-Methyl-3'-DMT Uridine 5'-CED phosphoramidite
Useful catalog search terms
- 2721427-32-1
- BRP-00430
- PA150
Physicochemical data
| InChIKey | ATKRAEVWEXDALJ-XKZJCBTISA-N |
|---|---|
| Nucleoside | 2'-O-methyluridine |
| 3'-O group | DMTr |
| 5'-O group | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| Orientation | Reverse 3'-O-DMTr / 5'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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