2′-F / Phosphoramidites
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite
Quick view. A reverse-orientation N6-benzoyl 2'-fluoro-dA phosphoramidite with 3'-O-DMTr and a 5'-CE phosphoramidite group for research-use oligonucleotide synthesis. CAS 2227293-35-6. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 4 |
| Representative chemistry-platform program | avacincaptad pegol |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite is classified as 2′-f / phosphoramidites (Formula C47H51FN7O7P; molecular weight 875.94).
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite — Reverse-orientation 2'-fluoro-dA(Bz) building block for research-use oligonucleotide synthesis.
For 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMT-2'-F-dA(Bz)-5'-CE-Phosphoramidite
- 3'-DMT-2'F-dA(Bz) CEP
Useful catalog search terms
- 2227293-35-6
- PA139
- 4Z-A-267074
Physicochemical data
| Nucleoside | N6-benzoyl-2'-fluoro-deoxyadenosine |
|---|---|
| 3'-O group | DMTr |
| 5'-O group | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| Orientation | Reverse 3'-O-DMTr / 5'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite
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OR-RP-00083'-O-DMTr-2'-dT-5'-CE-Phosphoramidite
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OR-RP-0010Reverse Abasic Phosphoramidite
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OR-RP-0011N6-Benzoyl-3'-O-DMTr-2'-deoxyadenosine-5'-CE phosphoramidite
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OR-RP-00133'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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