2′-OMe / Phosphoramidites
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite
Quick view. 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite is a protected 2'-O-methyl adenosine reverse phosphoramidite for research-use oligonucleotide synthesis. CAS 1309448-27-8. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | onvuzosiran |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Related product programs
Product profile
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite is classified as protected 2'-o-methyl adenosine reverse phosphoramidite (Formula C48H54N7O8P; molecular weight 887.97).
3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite — Protected 2'-O-methyl adenosine reverse phosphoramidite building block for research-use solid-phase oligonucleotide synthesis.
For 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite
- 3'-DMT-2'-OMe-A(Bz)-CE Reverse
Useful catalog search terms
- 1309448-27-8
- C48H54N7O8P
- Reverse Phosphoramidites
- ZTDLWOHDFXTWBU-PSVHYZMASA-N
- PubChem CID 178245187
Physicochemical data
| Key structural motifs | N6-benzoyl protection, 3'-DMT protection, 2'-O-methyl substitution, and a 5'-cyanoethyl N,N-diisopropyl phosphoramidite |
|---|---|
| PubChem CID | 178245187 |
| InChIKey | ZTDLWOHDFXTWBU-PSVHYZMASA-N |
| InChI | InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(60-28-14-27-49)61-29-40-42(43(59-7)47(62-40)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)63-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OC)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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