2′-MOE / Nucleoside Intermediates
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine
Quick view. An N6-benzoyl and 5'-O-DMT-protected 2'-O-methoxyethyl adenosine intermediate for research involving MOE-modified nucleoside chemistry. CAS 251647-48-0. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 20.6 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine is classified as 2′-moe / nucleoside intermediates (Formula C41H41N5O8; molecular weight 731.80).
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine — Research intermediate for 2'-O-MOE-modified nucleoside chemistry
For N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine, storage: 2-8 C, dark and dry; confirm lot-specific documentation.
Names and search terms
Confirmed or normalized name variants
- N6-Bz-DMT-2'-O-MOE-Ar
Useful catalog search terms
- N6-Benzoyl-5'-O-DMT-2'-O-MOE-adenosine
- 251647-48-0
Physicochemical data
| Modification | N6-benzoyl; 5'-O-DMT; 2'-O-methoxyethyl |
|---|---|
| Physical form | White, off-white to faint yellow powder |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O |
| PubChem CID | 21107951 |
| InChIKey | KEVMXGNDTKPSMC-MUMPVVMASA-N |
| InChI | InChI=1S/C41H41N5O8/c1-49-22-23-52-36-35(47)33(54-40(36)46-26-44-34-37(42-25-43-38(34)46)45-39(48)27-10-6-4-7-11-27)24-53-41(28-12-8-5-9-13-28,29-14-18-31(50-2)19-15-29)30-16-20-32(51-3)21-17-30/h4-21,25-26,33,35-36,40,47H,22-24H2,1-3H3,(H,42,43,45,48)/t33-,35-,36-,40-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.