2′-MOE / Nucleoside Intermediates
N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine
Quick view. An N2-protected 2'-O-MOE guanosine intermediate for nucleoside and oligonucleotide synthesis research. CAS 440327-50-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 18 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine is classified as 2′-moe / nucleoside intermediates (Formula C17H25N5O7; molecular weight 411.41).
N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine — N2-protected 2'-O-MOE guanosine intermediate for nucleoside and oligonucleotide synthesis research.
For N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-2'-O-MOE-guanosine
- 2'-O-MOE-N2-iBu-G
Useful catalog search terms
- CAS 440327-50-4
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Sugar modification | 2'-O-(2-methoxyethyl) |
| 5' functionality | Free hydroxyl |
| 3' functionality | Free hydroxyl |
| Physical form | Solid |
| Storage temperature | -20 C |
| PubChem CID | 136162613 |
| InChI | InChI=1S/C17H25N5O7/c1-8(2)14(25)20-17-19-13-10(15(26)21-17)18-7-22(13)16-12(28-5-4-27-3)11(24)9(6-23)29-16/h7-9,11-12,16,23-24H,4-6H2,1-3H3,(H2,19,20,21,25,26)/t9-,11-,12-,16-/m1/s1 |
| InChIKey | IZOOGJIUOCHAAY-UBEDBUPSSA-N |
| SMILES | COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(=O)[nH]c(NC(=O)C(C)C)nc21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.