2′-MOE / Nucleoside Intermediates
2'-O-(2-Methoxyethyl)-5-methyluridine
Quick view. 2'-O-(2-Methoxyethyl)-5-methyluridine is a 2'-O-MOE-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 163759-49-7. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 63.3 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-O-(2-Methoxyethyl)-5-methyluridine is classified as 2'-o-moe nucleoside (Formula C13H20N2O7; molecular weight 316.31).
2'-O-(2-Methoxyethyl)-5-methyluridine — A 2'-O-MOE-modified 5-methyluridine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-(2-Methoxyethyl)-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-5-Me-rU
- 5-Me-2'-O-MOE Uridine
- Uridine, 2'-O-(2-methoxyethyl)-5-methyl-
Useful catalog search terms
- CAS 163759-49-7
Physicochemical data
| PubChem CID | 11243988 |
|---|---|
| InChIKey | NEVQCHBUJFYGQO-DNRKLUKYSA-N |
| Modification | 2-methoxyethyl ether at the ribose 2'-oxygen and methyl at uracil C5 |
| InChI | InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-(2-Methoxyethyl)-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.