2′-MOE / Nucleoside Intermediates
2'-O-(2-Methoxyethyl)adenosine
Quick view. 2'-O-(2-Methoxyethyl)adenosine is a 2'-O-MOE-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 168427-74-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Development context | ↑ Upstream — reviewed as a supporting input; no direct development phase is assigned |
| CAS status | Published registry number |
Product profile
2'-O-(2-Methoxyethyl)adenosine is classified as 2'-o-moe nucleoside (Formula C13H19N5O5; molecular weight 325.32).
2'-O-(2-Methoxyethyl)adenosine — A 2'-O-(2-methoxyethyl)-modified adenosine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-(2-Methoxyethyl)adenosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rA
- 2'-O-MOE-A
- Adenosine, 2'-O-(2-methoxyethyl)-
Useful catalog search terms
- CAS 168427-74-5
Physicochemical data
| PubChem CID | 11393191 |
|---|---|
| InChIKey | PUDXUJRJLRLJIU-QYVSTXNMSA-N |
| Modification | 2-methoxyethyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C13H19N5O5/c1-21-2-3-22-10-9(20)7(4-19)23-13(10)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-(2-Methoxyethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
OR-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
OR-MN-01742'-O-(2-Methoxyethyl)-5-methyluridine
2'-O-MOE Nucleosides · CAS: 163759-49-7
OR-2MOE-0022N2-Isobutyryl-2'-O-(2-methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 440327-50-4
OR-2MOE-0033N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine
2'-O-MOE Nucleosides · CAS: 251647-48-0
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.