Morpholino PMO / Nucleoside Intermediates
7'-Hydroxy-N-trityl morpholino thymine
Quick view. A trityl-protected morpholino thymine precursor with a hydroxymethyl functional handle. CAS 914361-76-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 4 |
| Representative chemistry-platform program | casimersen |
| Planning-model annual demand | 214.6 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
7'-Hydroxy-N-trityl morpholino thymine is classified as morpholino pmo / nucleoside intermediates (Formula C29H29N3O4; molecular weight 483.56 g/mol).
7'-Hydroxy-N-trityl morpholino thymine — Trityl-protected morpholino thymine precursor for downstream PMO monomer chemistry.
For 7'-Hydroxy-N-trityl morpholino thymine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- PMO thymidine precursor
- 7'-OH-N-trityl morpholino thymine
Useful catalog search terms
- 914361-76-5
Physicochemical data
| Systematic name | 1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
|---|---|
| Base | Thymine |
| Ring system | Morpholino |
| Protecting group | N-Trityl |
| Functional handle | Hydroxymethyl |
| PubChem CID | 16662130 |
| InChI | InChI=1S/C29H29N3O4/c1-21-17-32(28(35)30-27(21)34)26-19-31(18-25(20-33)36-26)29(22-11-5-2-6-12-22,23-13-7-3-8-14-23)24-15-9-4-10-16-24/h2-17,25-26,33H,18-20H2,1H3,(H,30,34,35)/t25-,26+/m0/s1 |
| InChIKey | SINOYLIIFJJPCM-IZZNHLLZSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2CN(C[C@H](O2)CO)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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