N3′→P5′ Thiophosphoramidate / Nucleoside Intermediates
N4-Benzoyl-3'-amino-2',3'-dideoxycytidine
Quick view. An N4-protected, 3'-amino dideoxycytidine nucleoside for research involving amino-modified nucleoside chemistry. CAS 1418009-22-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | imetelstat |
| Planning-model annual demand | 3.5 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
N4-Benzoyl-3'-amino-2',3'-dideoxycytidine is classified as n3′→p5′ thiophosphoramidate / nucleoside intermediates (Formula C16H18N4O4; molecular weight 330.34).
N4-Benzoyl-3'-amino-2',3'-dideoxycytidine — Research material for studies involving N4-protected 3'-amino dideoxycytidine
For N4-Benzoyl-3'-amino-2',3'-dideoxycytidine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- N4-Bz-3'-NH2-ddC
Useful catalog search terms
- 1418009-22-9
- MFCD22373358
Physicochemical data
| Modification | N4-benzoyl; 3'-amino; 2',3'-dideoxy |
|---|---|
| MDL number | MFCD22373358 |
| PubChem CID | 138375989 |
| InChIKey | VZBOFUQWGKRAJQ-OUCADQQQSA-N |
| InChI | InChI=1S/C16H18N4O4/c17-11-8-14(24-12(11)9-21)20-7-6-13(19-16(20)23)18-15(22)10-4-2-1-3-5-10/h1-7,11-12,14,21H,8-9,17H2,(H,18,19,22,23)/t11-,12+,14+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe N4-Benzoyl-3'-amino-2',3'-dideoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.