N3′→P5′ Thiophosphoramidate / Nucleoside Intermediates
3'-Amino-3'-deoxythymidine
Quick view. A 3'-amino-substituted deoxythymidine derivative reported as a parent scaffold for amino-acyl derivatization. CAS 52450-18-7. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | imetelstat |
| Planning-model annual demand | 9.2 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
3'-Amino-3'-deoxythymidine is classified as n3′→p5′ thiophosphoramidate / nucleoside intermediates (Formula C10H15N3O4; molecular weight 241.24 g/mol).
3'-Amino-3'-deoxythymidine — Reported in peer-reviewed synthesis literature as a parent scaffold for preparing amino-acyl derivatives.
For 3'-Amino-3'-deoxythymidine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 3'-Aminothymidine
- 3'-amino-ddT
Useful catalog search terms
- 52450-18-7
- PubChem CID 108074
Physicochemical data
| PubChem CID | 108074 |
|---|---|
| IUPAC name | 1-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| InChIKey | ADVCGXWUUOVPPB-XLPZGREQSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 3'-Amino-3'-deoxythymidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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