N3′→P5′ Thiophosphoramidate / Nucleoside Intermediates
3'-NH₂-ddG
Quick view. A guanine nucleoside analog bearing a 3'-amino group, no 2'-hydroxyl group, and an unprotected 5'-hydroxyl group. CAS 66323-49-7. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | imetelstat |
| Planning-model annual demand | 14 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
3'-NH₂-ddG is classified as n3′→p5′ thiophosphoramidate / nucleoside intermediates (Formula C10H14N6O3; molecular weight 266.26).
3'-NH₂-ddG is supplied for research use within the Amino-modified Nucleosides product family.
For 3'-NH₂-ddG, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-Amino-2',3'-dideoxyguanosine
Useful catalog search terms
- CAS 66323-49-7
Physicochemical data
| InChIKey | HOQBPAWPBCAUGA-KVQBGUIXSA-N |
|---|---|
| Nucleobase | Guanine |
| Sugar modification | 2',3'-dideoxy with 3'-amino substitution |
| Hydroxyl state | 5' hydroxyl group unprotected |
| InChI | InChI=1S/C10H14N6O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2,11H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1 |
| SMILES | N=c1nc(O)c2ncn([C@H]3C[C@H](N)[C@@H](CO)O3)c2[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.