GalNAc Ligands / Phosphoramidites
GalNAc-THA C6 Phosphoramidite
Quick view. GalNAc Ligands / Phosphoramidites-THA C6 Phosphoramidite is a GalNAc-containing phosphoramidite building block identified by CAS 2058062-52-3 for research-use oligonucleotide synthesis. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 3 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 5.8 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
GalNAc-THA C6 Phosphoramidite is classified as galnac-containing phosphoramidite (Formula C93H155N10O37P; molecular weight 2036.25).
GalNAc-THA C6 Phosphoramidite — GalNAc-containing phosphoramidite building block for research-use oligonucleotide synthesis.
For GalNAc-THA C6 Phosphoramidite, in-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
Names and search terms
Useful catalog search terms
- GalNAc-THA-C6 phosphoramidite
- CAS 2058062-52-3
- C93H155N10O37P
- GalNAc
Physicochemical data
| PubChem CID | 177927309 |
|---|---|
| InChIKey | AQRSTPBSCQPPBQ-KAKHWKMQSA-N |
| InChI | InChI=1S/C93H155N10O37P/c1-59(2)103(60(3)4)141(131-49-34-40-94)130-48-32-24-20-28-41-95-76(116)35-33-36-80(120)102-93(56-121-50-37-77(117)96-42-25-17-21-29-45-124-90-81(99-61(5)104)87(135-70(14)113)84(132-67(11)110)73(138-90)53-127-64(8)107,57-122-51-38-78(118)97-43-26-18-22-30-46-125-91-82(100-62(6)105)88(136-71(15)114)85(133-68(12)111)74(139-91)54-128-65(9)108)58-123-52-39-79(119)98-44-27-19-23-31-47-126-92-83(101-63(7)106)89(137-72(16)115)86(134-69(13)112)75(140-92)55-129-66(10)109/h59-60,73-75,81-92H,17-39,41-58H2,1-16H3,(H,95,116)(H,96,117)(H,97,118)(H,98,119)(H,99,104)(H,100,105)(H,101,106)(H,102,120)/t73-,74-,75-,81-,82-,83-,84+,85+,86+,87-,88-,89-,90-,91-,92-,141?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCC(=O)NC(COCCC(=O)NCCCCCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COCCC(=O)NCCCCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)OCCC#N |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCC(=O)NC(COCCC(=O)NCCCCCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COCCC(=O)NCCCCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)OCCC#N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe GalNAc-THA C6 Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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