GalNAc Ligands / Phosphoramidites
AdemA-GalNAc Phosphoramidite
Quick view. AdemA-GalNAc Ligands / Phosphoramidites Phosphoramidite is a GalNAc-linked protected phosphoramidite identified by CAS 1953147-02-8 for nucleic acid synthesis. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | nedosiran |
| Planning-model annual demand | 0.8 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
AdemA-GalNAc Phosphoramidite is classified as galnac ligands / phosphoramidites (Formula C71H90N9O20P; molecular weight 1420.50).
AdemA-GalNAc Phosphoramidite — Phosphoramidite building block for nucleic acid synthesis.
For AdemA-GalNAc Phosphoramidite, in-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
Names and search terms
Useful catalog search terms
- CAS 1953147-02-8
- GalNAc
Physicochemical data
| InChIKey | BRDKHUNHNBOUJH-DVERYZRGSA-N |
|---|---|
| InChI | InChI=1S/C71H90N9O20P/c1-45(2)80(46(3)4)101(95-36-19-33-72)100-63-58(41-94-71(52-22-15-12-16-23-52,53-25-29-55(87-9)30-26-53)54-27-31-56(88-10)32-28-54)98-69(79-43-76-61-66(74-42-75-67(61)79)78-68(86)51-20-13-11-14-21-51)65(63)93-44-90-39-38-89-37-34-73-59(85)24-17-18-35-91-70-60(77-47(5)81)64(97-50(8)84)62(96-49(7)83)57(99-70)40-92-48(6)82/h11-16,20-23,25-32,42-43,45-46,57-58,60,62-65,69-70H,17-19,24,34-41,44H2,1-10H3,(H,73,85)(H,77,81)(H,74,75,78,86)/t57-,58-,60-,62+,63-,64-,65-,69-,70-,101?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOCCOCCNC(=O)CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCOCCOCCNC(=O)CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC |
| PubChem CID | 156645982 |
| Structure representation | Exact protected AdemA-GalNAc phosphoramidite identity; phosphorus configuration is unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe AdemA-GalNAc Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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