Natural RNA / Nucleoside Intermediates
5'-O-DMTr-2'-O-TBDMS-rU
Quick view. Uridine bearing a 5'-O-DMTr group, a 2'-O-TBDMS group and a free 3'-hydroxyl. CAS 81246-80-2. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | patisiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-TBDMS-rU is classified as natural rna / nucleoside intermediates (Formula C36H44N2O8Si; molecular weight 660.83).
5'-O-DMTr-2'-O-TBDMS-rU is supplied for research use within the DMTr-protected Nucleosides product family.
For 5'-O-DMTr-2'-O-TBDMS-rU, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2'-O-TBDMS-5'-O-DMTr-uridine
- 5'-O-DMT-2'-O-TBDMS-U
Useful catalog search terms
- CAS 81246-80-2
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr; 2'-O-TBDMS |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-31(40)29(45-33(32)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s1 |
| InChIKey | KVHQIELPHWJPSY-WXQJYUTRSA-N |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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