LNA / Nucleoside Intermediates
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu)
Quick view. N2-isobutyryl-protected LNA guanosine bearing a 5'-O-DMTr group, a 2'-O,4'-C methylene bridge and a free 3'-hydroxyl. CAS 206055-72-3. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | rugonersen |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is classified as lna / nucleoside intermediates (Formula C36H37N5O8; molecular weight 667.71).
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-LNA-N2-iBu-G
- 5'-ODMT-LNA-G(iBu)
Useful catalog search terms
- CAS 206055-72-3
Physicochemical data
| Nucleoside | LNA guanosine |
|---|---|
| Base protection | N2-isobutyryl |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar bridge | 2'-O,4'-C methylene |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)
DMTr-protected Nucleosides · CAS: 445012-77-1
OR-PN-00335'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU
DMTr-protected Nucleosides · CAS: 206055-71-2
OR-PN-00345'-O-DMTr-2'-O-4'-C-Locked-rA(Bz)
DMTr-protected Nucleosides · CAS: 206055-74-5
OR-PN-00375'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)
DMTr-protected Nucleosides · CAS: 182496-01-1
OR-PN-00385'-O-DMTr-2'-O-MOE-5-Me-rU
DMTr-protected Nucleosides · CAS: 163759-50-0
OR-PN-00405'-O-DMTr-2'-O-MOE-rG(iBu)
DMTr-protected Nucleosides · CAS: 251647-50-4
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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