2′-MOE / Nucleoside Intermediates
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)
Quick view. N4-benzoyl-protected 5-methylcytidine bearing a 5'-O-DMTr group, a 2'-O-(2-methoxyethyl) substituent and a free 3'-hydroxyl. CAS 182496-01-1. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 63.9 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) is classified as 2′-moe / nucleoside intermediates (Formula C41H43N3O9; molecular weight 721.79).
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine
- DMT-2'-O-MOE-C(Bz)
Useful catalog search terms
- CAS 182496-01-1
Physicochemical data
| Nucleoside | 5-methylcytidine |
|---|---|
| Base protection | N4-benzoyl |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C41H43N3O9/c1-27-25-44(40(47)43-37(27)42-38(46)28-11-7-5-8-12-28)39-36(51-24-23-48-2)35(45)34(53-39)26-52-41(29-13-9-6-10-14-29,30-15-19-32(49-3)20-16-30)31-17-21-33(50-4)22-18-31/h5-22,25,34-36,39,45H,23-24,26H2,1-4H3,(H,42,43,46,47)/t34-,35-,36-,39-/m1/s1 |
| InChIKey | BYSCLUAIKFEFAH-LZURGKRNSA-N |
| SMILES | CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.