Natural RNA / Nucleoside Intermediates
5'-O-DMTr-2'-O-TBDMS-rG(iBu)
Quick view. N2-isobutyryl-protected guanosine bearing a 5'-O-DMTr group, a 2'-O-TBDMS group and a free 3'-hydroxyl. CAS 81279-39-2. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | patisiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-TBDMS-rG(iBu) is classified as natural rna / nucleoside intermediates (Formula C41H51N5O8Si; molecular weight 769.96).
5'-O-DMTr-2'-O-TBDMS-rG(iBu) is supplied for research use within the DMTr-protected Nucleosides product family.
For 5'-O-DMTr-2'-O-TBDMS-rG(iBu), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-5'-O-DMTr-2'-O-TBDMS-guanosine
- 5'-O-DMT-2'-O-TBDMS-N2-iBu-G
Useful catalog search terms
- CAS 81279-39-2
Physicochemical data
| Nucleoside | Guanosine |
|---|---|
| Base protection | N2-isobutyryl |
| Hydroxyl protection | 5'-O-DMTr; 2'-O-TBDMS |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-34(54-55(8,9)40(3,4)5)33(47)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s1 |
| InChIKey | JMCNKJFOIJGYRG-CJEGOSRCSA-N |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(O)nc(NC(=O)C(C)C)nc43)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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