Natural RNA / Nucleoside Intermediates
5'-O-DMTr-2'-O-TBDMS-rA(Bz)
Quick view. N6-benzoyl-protected adenosine bearing a 5'-O-DMTr group, a 2'-O-TBDMS group and a free 3'-hydroxyl. CAS 81265-93-2. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | patisiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-TBDMS-rA(Bz) is classified as natural rna / nucleoside intermediates (Formula C44H49N5O7Si; molecular weight 788.00 g/mol).
5'-O-DMTr-2'-O-TBDMS-rA(Bz) is supplied for research use within the DMTr-protected Nucleosides product family.
For 5'-O-DMTr-2'-O-TBDMS-rA(Bz), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-5'-O-DMTr-2'-O-TBDMS-adenosine
- 5'-O-DMT-2'-O-TBDMS-N6-Bz-A
Useful catalog search terms
- PubChem CID 13871229
- CAS 81265-93-2
Physicochemical data
| PubChem CID | 13871229 |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-benzoyl |
| Hydroxyl protection | 5'-O-DMTr; 2'-O-TBDMS |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C44H49N5O7Si/c1-43(2,3)57(6,7)56-38-37(50)35(55-42(38)49-28-47-36-39(45-27-46-40(36)49)48-41(51)29-14-10-8-11-15-29)26-54-44(30-16-12-9-13-17-30,31-18-22-33(52-4)23-19-31)32-20-24-34(53-5)25-21-32/h8-25,27-28,35,37-38,42,50H,26H2,1-7H3,(H,45,46,48,51)/t35-,37-,38-,42-/m1/s1 |
| InChIKey | DAZIGOPASNJPCJ-GNECSJIWSA-N |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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