2′-MOE / Nucleoside Intermediates
5'-O-DMTr-2'-O-MOE-rG(iBu)
Quick view. N2-isobutyryl-protected guanosine bearing a 5'-O-DMTr group, a 2'-O-(2-methoxyethyl) substituent and a free 3'-hydroxyl. CAS 251647-50-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 18 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-MOE-rG(iBu) is classified as 2′-moe / nucleoside intermediates (Formula C38H43N5O9; molecular weight 713.78).
5'-O-DMTr-2'-O-MOE-rG(iBu) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-DMTr-2'-O-MOE-rG(iBu), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
- N2-iBu-DMT-2'-O-MOE-G
Useful catalog search terms
- CAS 251647-50-4
Physicochemical data
| Nucleoside | Guanosine |
|---|---|
| Base protection | N2-isobutyryl |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)
DMTr-protected Nucleosides · CAS: 445012-77-1
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DMTr-protected Nucleosides · CAS: 206055-71-2
OR-PN-00345'-O-DMTr-2'-O-4'-C-Locked-rA(Bz)
DMTr-protected Nucleosides · CAS: 206055-74-5
OR-PN-00365'-O-DMTr-2'-O-4'-C-Locked-rG(iBu)
DMTr-protected Nucleosides · CAS: 206055-72-3
OR-PN-00375'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)
DMTr-protected Nucleosides · CAS: 182496-01-1
OR-PN-00385'-O-DMTr-2'-O-MOE-5-Me-rU
DMTr-protected Nucleosides · CAS: 163759-50-0
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.