2′-OMe / Nucleoside Intermediates
5'-O-DMTr-2'-O-Me-rU
Quick view. 2'-O-Methyluridine bearing a 5'-O-DMTr group and a free 3'-hydroxyl group. CAS 103285-22-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 758.9 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-Me-rU is classified as 2′-ome / nucleoside intermediates (Formula C31H32N2O8; molecular weight 560.60).
5'-O-DMTr-2'-O-Me-rU supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-DMTr-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyluridine
- 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-methyluridine
Useful catalog search terms
- CAS 103285-22-9
Physicochemical data
| PubChem CID | 11039002 |
|---|---|
| InChIKey | MFDHAVFJDSRPKC-YXINZVNLSA-N |
| Nucleoside | Uridine |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)40-19-25-27(35)28(39-3)29(41-25)33-18-17-26(34)32-30(33)36/h4-18,25,27-29,35H,19H2,1-3H3,(H,32,34,36)/t25-,27-,28-,29-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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