2′-F / Nucleoside Intermediates
5'-O-DMTr-2'-F-dG(iBu)
Quick view. N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine bearing a 5'-O-DMTr group with a free 3'-hydroxyl group. CAS 144089-96-3. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 143.2 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-F-dG(iBu) is classified as 2′-f / nucleoside intermediates (Formula C35H36FN5O7; molecular weight 657.70).
5'-O-DMTr-2'-F-dG(iBu) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-F-dG(iBu), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-N2-isobutyryl-2'-deoxyguanosine
- 5'-O-DMT-N2-iBu-2'-F-dG
Useful catalog search terms
- N2-Isobutyryl-5'-O-DMTr-2'-fluoro-2'-deoxyguanosine
- CAS 144089-96-3
Physicochemical data
| Nucleoside | N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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DMTr-protected Nucleosides · CAS: 163759-50-0
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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