2′-F / Nucleoside Intermediates
5'-O-DMTr-2'-F-dC(Ac)
Quick view. N4-Acetyl-2'-fluoro-2'-deoxycytidine bearing a 5'-O-DMTr group with a free 3'-hydroxyl group. CAS 159414-98-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 261.7 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-F-dC(Ac) is classified as 2′-f / nucleoside intermediates (Formula C32H32FN3O7; molecular weight 589.61).
5'-O-DMTr-2'-F-dC(Ac) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-F-dC(Ac), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluorocytidine
- 5'-O-DMT-N4-Ac-2'-F-dC
Useful catalog search terms
- N4-Acetyl-5'-O-DMTr-2'-fluoro-2'-deoxycytidine
- CAS 159414-98-9
Physicochemical data
| InChIKey | JIFNUYITABZZQS-PYYPWFDZSA-N |
|---|---|
| Nucleoside | N4-Acetyl-2'-fluoro-2'-deoxycytidine |
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C32H32FN3O7/c1-20(37)34-27-17-18-36(31(39)35-27)30-28(33)29(38)26(43-30)19-42-32(21-7-5-4-6-8-21,22-9-13-24(40-2)14-10-22)23-11-15-25(41-3)16-12-23/h4-18,26,28-30,38H,19H2,1-3H3,(H,34,35,37,39)/t26-,28-,29-,30-/m1/s1 |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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