2′-MOE / Phosphoramidites
DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite is a 2'-O-(2-methoxyethyl) 5-methyluridine building block for research-use oligonucleotide synthesis. CAS 163878-63-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 67.3 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite is classified as 2'-o-moe 5-methyluridine phosphoramidite (Formula C43H55N4O10P; molecular weight 818.90).
DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite — 2'-O-(2-methoxyethyl) 5-methyluridine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-T Phosphoramidite
- 2'-O-MOE-5-Me-U Phosphoramidite
- 5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-3'-CE Phosphoramidite
Useful catalog search terms
- 163878-63-5
- PubChem 92043625
- C43H55N4O10P
Physicochemical data
| Base modification | 5-methyl |
|---|---|
| Ribose modification | 2'-O-(2-methoxyethyl) |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | YFRRKZDUDXHJNC-KZQAAKLLSA-N |
| InChI | InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26-25-50-6)46-27-31(5)40(48)45-42(46)49)28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC |
| PubChem CID | 92043625 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.