2′-OMe / Phosphoramidites
DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite
Quick view. A 5'-O-DMTr-protected 2'-O-methyl inosine CE phosphoramidite for oligonucleotide synthesis research. CAS 128219-85-2. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | plozasiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite is classified as 2′-ome / phosphoramidites (Formula C41H49N6O8P; molecular weight 784.84).
DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite — Protected 2'-O-methyl inosine phosphoramidite building block for oligonucleotide synthesis research.
For DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methylinosine-3'-CE phosphoramidite
- 2'-OMe-I Phosphoramidite
- 2'-O-Methyl-5'-O-DMT-inosine-3'-CE phosphoramidite
Useful catalog search terms
- CAS 128219-85-2
- PVFNTYBGWVZMCX-HLHZJIEZSA-N
Physicochemical data
| InChIKey | PVFNTYBGWVZMCX-HLHZJIEZSA-N |
|---|---|
| Nucleobase identity | Inosine |
| Ribose modification | 2'-O-methyl |
| 5' protection | 5'-O-DMTr |
| Coupling group | 3'-CE phosphoramidite |
| Phosphorus stereochemistry | Unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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