2′-OMe / Phosphoramidites
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite
Quick view. A stereodefined D-DPSE phosphoramidite of 5'-O-DMTr, 2'-O-methyl, N2-isobutyrylguanosine for oligonucleotide synthesis research. CAS 2227139-99-1. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 4 |
| Representative chemistry-platform program | WVE-N531 |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Related product programs
Product profile
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite is classified as 2′-ome / phosphoramidites (Formula C55H61N6O9PSi; molecular weight 1009.17).
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite — Protected stereodefined D-DPSE guanosine phosphoramidite monomer for oligonucleotide synthesis research.
For 5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-Phosphoramidite
- DMT-2'-O-Me-rG(iBu)-3'-(D)-DPSE phosphoramidite
Useful catalog search terms
- CAS 2227139-99-1
- OXZJTILABONBRI-ULXZQQBCSA-N
Physicochemical data
| InChIKey | OXZJTILABONBRI-ULXZQQBCSA-N |
|---|---|
| Nucleoside | 5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine |
| Chiral auxiliary | (D)-DPSE cyclic phosphoramidite |
| Stereochemical boundary | Reagent stereochemistry defined; final linkage outcome not asserted |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-DPSE phosphoramidite
2'-O-Me Phosphoramidites · CAS: 1528733-91-6
OR-2OMP-00315'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-PSM phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2379296-27-0
OR-2OMP-00325'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(L)-PSM phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2379296-17-8
OR-2OMP-0033DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
OR-2OMP-00375'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-DPSE phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2227139-95-7
OR-2OMP-00385'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-PSM phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.