2′-OMe / Phosphoramidites
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite is an N4-acetyl-protected 2'-O-methyl cytidine building block for research-use oligonucleotide synthesis. CAS 199593-09-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 286.2 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl cytidine phosphoramidite (Formula C42H52N5O9P; molecular weight 801.90).
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite — N4-acetyl-protected 2'-O-methyl cytidine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-C(Ac) Phosphoramidite
- DMT-2'-O-methyl-rC(Ac) Phosphoramidite
- N4-Acetyl-5'-O-DMTr-2'-O-methylcytidine-3'-CE Phosphoramidite
Useful catalog search terms
- 199593-09-4
- C42H52N5O9P
Physicochemical data
| Base protection | N4-acetyl |
|---|---|
| Ribose modification | 2'-O-methyl |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChI | InChI=1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39+,40-,57?/m1/s1 |
| InChIKey | WNWUMIPFLOKTEZ-MNVCMFJRSA-N |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(NC(C)=O)nc3=O)[C@@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.