2′-OMe / Phosphoramidites
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is an N6-benzoyl-protected 2'-O-methyl adenosine building block for research-use oligonucleotide synthesis. CAS 110782-31-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 707 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl adenosine phosphoramidite (Formula C48H54N7O8P; molecular weight 888.00).
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite — N6-benzoyl-protected 2'-O-methyl adenosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-A(Bz) Phosphoramidite
- DMT-2'-O-methyl-rA(Bz) Phosphoramidite
- N6-Benzoyl-5'-O-DMTr-2'-O-methyladenosine-3'-CE Phosphoramidite
Useful catalog search terms
- 110782-31-5
- PubChem 13872235
- C48H54N7O8P
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| Ribose modification | 2'-O-methyl |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | AZCGOTUYEPXHMJ-PSVHYZMASA-N |
| InChI | InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-DPSE phosphoramidite
2'-O-Me Phosphoramidites · CAS: 1528733-91-6
OR-2OMP-00315'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-PSM phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2379296-27-0
OR-2OMP-00325'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(L)-PSM phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2379296-17-8
OR-2OMP-0033DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
OR-2OMP-00365'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2227139-99-1
OR-2OMP-00375'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-DPSE phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2227139-95-7
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.