2′-OMe / Phosphoramidites
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite
Quick view. 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite is a POM-protected 5'-(E)-vinylphosphonate 2'-O-methyl uridine building block for research-use oligonucleotide synthesis. CAS 2172373-55-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | mivelsiran |
| Highest development phase | Phase II |
| CAS status | Published registry number |
Related product programs
Product profile
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite is classified as pom-protected vinylphosphonate nucleoside phosphoramidite (Formula C32H52N4O13P2; molecular weight 762.70).
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite — POM-protected 5'-(E)-vinylphosphonate 2'-O-methyl uridine phosphoramidite building block for research-use oligonucleotide synthesis.
For 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'(E)-VP-2'-OMe-U Phosphoramidite
- 5'(E)-VP-2'-O-methyl-U Phosphoramidite
Useful catalog search terms
- 2172373-55-4
- PubChem 172639621
- C32H52N4O13P2
- Synthgene PA052
Physicochemical data
| Ribose modification | 2'-O-methyl |
|---|---|
| 5' modification | POM-protected (E)-vinylphosphonate |
| 3' synthesis handle | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | AJJPYIXDIHURAB-FQIYNDLNSA-N |
| InChI | InChI=1S/C32H52N4O13P2/c1-21(2)36(22(3)4)50(45-17-12-15-33)49-25-23(48-27(26(25)42-11)35-16-13-24(37)34-30(35)40)14-18-51(41,46-19-43-28(38)31(5,6)7)47-20-44-29(39)32(8,9)10/h13-14,16,18,21-23,25-27H,12,17,19-20H2,1-11H3,(H,34,37,40)/b18-14+/t23-,25-,26-,27-,50?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OC)N2C=CC(=O)NC2=O)/C=C/P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C |
| PubChem CID | 172639621 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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