Natural RNA / Nucleoside Intermediates
5'-O-DMTr-2'-O-TBDMS-rC(Ac)
Quick view. N4-acetyl-protected cytidine bearing a 5'-O-DMTr group, a 2'-O-TBDMS group and a free 3'-hydroxyl. CAS 121058-85-3. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | patisiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
5'-O-DMTr-2'-O-TBDMS-rC(Ac) is classified as natural rna / nucleoside intermediates (Formula C38H47N3O8Si; molecular weight 701.90 g/mol).
5'-O-DMTr-2'-O-TBDMS-rC(Ac) is supplied for research use within the Protected Nucleosides product family.
For 5'-O-DMTr-2'-O-TBDMS-rC(Ac), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- N4-Acetyl-5'-O-DMTr-2'-O-TBDMS-cytidine
- 5'-O-DMT-2'-O-TBDMS-N4-Ac-C
Useful catalog search terms
- PubChem CID 11136250
- CAS 121058-85-3
Physicochemical data
| PubChem CID | 11136250 |
|---|---|
| Nucleoside | Cytidine |
| Base protection | N4-acetyl |
| Hydroxyl protection | 5'-O-DMTr; 2'-O-TBDMS |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C38H47N3O8Si/c1-25(42)39-32-22-23-41(36(44)40-32)35-34(49-50(7,8)37(2,3)4)33(43)31(48-35)24-47-38(26-12-10-9-11-13-26,27-14-18-29(45-5)19-15-27)28-16-20-30(46-6)21-17-28/h9-23,31,33-35,43H,24H2,1-8H3,(H,39,40,42,44)/t31-,33-,34-,35-/m1/s1 |
| InChIKey | ZFRWPAYPCFTQHK-HYGOWAQNSA-N |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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