2′-MOE / Nucleoside Intermediates
2'-O-MOE-rA(Bz)
Quick view. N6-Benzoyl adenosine bearing a 2'-O-(2-methoxyethyl) group and free 3'- and 5'-hydroxyl groups. CAS 333335-93-6. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | donidalorsen |
| Planning-model annual demand | 20.6 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-O-MOE-rA(Bz) is classified as 2′-moe / nucleoside intermediates (Formula C20H23N5O6; molecular weight 429.43).
2'-O-MOE-rA(Bz) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 2'-O-MOE-rA(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine
- N6-Bz-2'-O-MOE-rA
- 2'-O-MOE-N6-Bz-adenosine
Useful catalog search terms
- CAS 333335-93-6
Physicochemical data
| InChIKey | RUFJMCSVNNGZFB-KHTYJDQRSA-N |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-benzoyl |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C20H23N5O6/c1-29-7-8-30-16-15(27)13(9-26)31-20(16)25-11-23-14-17(21-10-22-18(14)25)24-19(28)12-5-3-2-4-6-12/h2-6,10-11,13,15-16,20,26-27H,7-9H2,1H3,(H,21,22,24,28)/t13-,15-,16-,20-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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