2′-F / Nucleoside Intermediates
2'-F-dC(Ac)
Quick view. N4-Acetyl-2'-fluoro-2'-deoxycytidine with free 3'- and 5'-hydroxyl groups. CAS 159414-97-8. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 261.7 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-F-dC(Ac) is classified as 2′-f / nucleoside intermediates (Formula C11H14FN3O5; molecular weight 287.24).
2'-F-dC(Ac) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-F-dC(Ac), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N4-Acetyl-2'-fluoro-2'-deoxycytidine
- N4-Ac-2'-F-dC
Useful catalog search terms
- CAS 159414-97-8
Physicochemical data
| PubChem CID | 22094552 |
|---|---|
| InChIKey | NLXVKEFNBVLDLD-PEBGCTIMSA-N |
| Nucleoside | 2'-Fluoro-2'-deoxycytidine |
| Base protection | N4-acetyl |
| Sugar modification | 2'-fluoro-2'-deoxy |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C11H14FN3O5/c1-5(17)13-7-2-3-15(11(19)14-7)10-8(12)9(18)6(4-16)20-10/h2-3,6,8-10,16,18H,4H2,1H3,(H,13,14,17,19)/t6-,8-,9-,10-/m1/s1 |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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