2′-OMe / Nucleoside Intermediates
2'-O-Methyluridine
Quick view. 2'-O-Methyluridine is a 2'-O-methyl-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 2140-76-3. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 758.9 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-O-Methyluridine is classified as 2'-o-methyl nucleoside (Formula C10H14N2O6; molecular weight 258.23).
2'-O-Methyluridine — A 2'-O-methyl-modified uridine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-Methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-rU
- Uridine, 2'-O-methyl-
Useful catalog search terms
- CAS 2140-76-3
Physicochemical data
| PubChem CID | 102212 |
|---|---|
| InChIKey | SXUXMRMBWZCMEN-ZOQUXTDFSA-N |
| Modification | methyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.