2′-OMe / Nucleoside Intermediates
2'-O-Methylguanosine
Quick view. 2'-O-Methylguanosine is a 2'-O-methyl-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 2140-71-8. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Development context | ↑ Upstream — reviewed as a supporting input; no direct development phase is assigned |
| CAS status | Published registry number |
Product profile
2'-O-Methylguanosine is classified as 2'-o-methyl nucleoside (Formula C11H15N5O5; molecular weight 297.27).
2'-O-Methylguanosine — A 2'-O-methyl-modified guanosine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-Methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-rG
- 2'-O-Methyl-D-guanosine
Useful catalog search terms
- CAS 2140-71-8
Physicochemical data
| PubChem CID | 135406950 |
|---|---|
| InChIKey | OVYNGSFVYRPRCG-KQYNXXCUSA-N |
| Modification | methyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC(=NC3=O)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.