2′-OMe / Nucleoside Intermediates
2'-O-Me-rG(iBu)
Quick view. N2-Isobutyryl-2'-O-methylguanosine with free 3'- and 5'-hydroxyl groups. CAS 63264-29-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 435.5 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-O-Me-rG(iBu) is classified as 2′-ome / nucleoside intermediates (Formula C15H21N5O6; molecular weight 367.36).
2'-O-Me-rG(iBu) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Me-rG(iBu), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-2'-O-methylguanosine
- N2-iBu-2'-O-Me-rG
Useful catalog search terms
- CAS 63264-29-9
Physicochemical data
| PubChem CID | 135536008 |
|---|---|
| InChIKey | RPULCYXEYODQOG-AKAIJSEGSA-N |
| Nucleoside | Guanosine |
| Base protection | N2-isobutyryl |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-4'-C-Locked-5-Me-rC(Bz)
Base-protected Nucleosides · CAS: 206055-81-4
OR-PN-00092'-O-4'-C-Locked-rG(iBu)
Base-protected Nucleosides · CAS: 206055-68-7
OR-PN-00802'-O-MOE-5-Me-rC(Bz)
Base-protected Nucleosides · CAS: 340162-93-8
OR-PN-00822'-O-MOE-rA(Bz)
Base-protected Nucleosides · CAS: 333335-93-6
OR-PN-00902'-O-4'-C-Locked-rA(Bz)
Base-protected Nucleosides · CAS: 209968-94-5
OR-PN-00962'-F-dA(Bz)
Base-protected Nucleosides · CAS: 136834-20-3
Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.