2′-OMe / Nucleoside Intermediates
2'-O-Me-rC(Ac)
Quick view. N4-Acetyl-2'-O-methylcytidine with free 3'- and 5'-hydroxyl groups. CAS 113886-71-8. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 269.4 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-O-Me-rC(Ac) is classified as 2′-ome / nucleoside intermediates (Formula C12H17N3O6; molecular weight 299.28).
2'-O-Me-rC(Ac) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Me-rC(Ac), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N4-Acetyl-2'-O-methylcytidine
- N4-Ac-2'-O-Me-rC
- Ac-2'-OMe-C
Useful catalog search terms
- CAS 113886-71-8
Physicochemical data
| PubChem CID | 10902616 |
|---|---|
| InChIKey | CYDFBLGNJUNSCC-QCNRFFRDSA-N |
| Nucleoside | Cytidine |
| Base protection | N4-acetyl |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C12H17N3O6/c1-6(17)13-8-3-4-15(12(19)14-8)11-10(20-2)9(18)7(5-16)21-11/h3-4,7,9-11,16,18H,5H2,1-2H3,(H,13,14,17,19)/t7-,9-,10-,11-/m1/s1 |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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