2′-OMe / Nucleoside Intermediates
N6-Benzoyl-2'-O-methyladenosine
Quick view. An N6-benzoyl-protected adenosine building block bearing a 2'-O-methyl substituent and free 3'- and 5'-hydroxyl groups. CAS 85079-00-1. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 8 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 665.5 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
N6-Benzoyl-2'-O-methyladenosine is classified as 2′-ome / nucleoside intermediates (Formula C18H19N5O5; molecular weight 385.38).
N6-Benzoyl-2'-O-methyladenosine — Identity-defined, base-protected 2'-O-methyl nucleoside building block for research workflows involving nucleoside, nucleotide, and oligonucleotide chemistry.
For N6-Benzoyl-2'-O-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-rA(Bz)
- N6-Bz-2'-OMe-rA
- 2'-O-Methyl-N6-benzoyladenosine
Useful catalog search terms
- CAS 85079-00-1
Physicochemical data
| Systematic name | N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]purin-6-yl]benzamide |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-Benzoyl |
| Sugar modification | 2'-O-Methyl |
| Free hydroxyl groups | 3' and 5' |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O |
| InChI | InChI=1S/C18H19N5O5/c1-27-14-13(25)11(7-24)28-18(14)23-9-21-12-15(19-8-20-16(12)23)22-17(26)10-5-3-2-4-6-10/h2-6,8-9,11,13-14,18,24-25H,7H2,1H3,(H,19,20,22,26)/t11-,13-,14-,18-/m1/s1 |
| InChIKey | PHFHSPQCDRKMQJ-XWXWGSFUSA-N |
| PubChem CID | 13852840 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6-Benzoyl-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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