2′-F / Nucleoside Intermediates
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine
Quick view. A guanosine building block bearing an N2-isobutyryl protecting group, a 2'-fluoro substituent, and free 3'- and 5'-hydroxyl groups. CAS 80681-25-0. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 143.2 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine is classified as 2′-f / nucleoside intermediates (Formula C14H18FN5O5; molecular weight 355.32).
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine — Identity-defined 2'-fluoro base-protected nucleoside building block for research workflows involving modified nucleoside, nucleotide, and oligonucleotide chemistry.
For N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dG(iBu)
- N2-iBu-2'-F-dG
- 2'-Deoxy-2'-fluoro-N-isobutyrylguanosine
- iBu-2'-F-dG
Useful catalog search terms
- CAS 80681-25-0
Physicochemical data
| InChIKey | SLHADUUWJSVYGQ-HTFXMJNNSA-N |
|---|---|
| Furanose stereochemistry | (2R,3R,4R,5R) |
| Nucleoside | 2'-Fluoro-2'-deoxyguanosine |
| Base protection | N2-Isobutyryl |
| Free hydroxyl groups | 3' and 5' |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)F |
| InChI | InChI=1S/C14H18FN5O5/c1-5(2)11(23)18-14-17-10-8(12(24)19-14)16-4-20(10)13-7(15)9(22)6(3-21)25-13/h4-7,9,13,21-22H,3H2,1-2H3,(H2,17,18,19,23,24)/t6-,7-,9-,13-/m1/s1 |
| PubChem CID | 135742141 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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