mRNA and Delivery / Nucleoside Intermediates
1-Methylpseudouridine
Quick view. 1-Methylpseudouridine is an N1-methylated C-nucleoside building block for research-use modified-nucleoside and RNA chemistry. CAS 13860-38-3. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | Spikevax |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
1-Methylpseudouridine is classified as methylated pseudouridine c-nucleoside (Formula C10H14N2O6; molecular weight 258.23).
An N1-methylpseudouridine building block for research-use modified-nucleoside and RNA chemistry.
For 1-Methylpseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- N1-Me-Pseudouridine
- N1-Methylpseudouridine
- 1-Methyl-5-(beta-D-ribofuranosyl)pyrimidine-2,4-dione
Useful catalog search terms
- CAS 13860-38-3
Physicochemical data
| PubChem CID | 99543 |
|---|---|
| InChIKey | UVBYMVOUBXYSFV-XUTVFYLZSA-N |
| Modification | methyl at pyrimidine N1 |
| InChI | InChI=1S/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,8+/m1/s1 |
| SMILES | CN1C=C(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 1-Methylpseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.