Conjugation Linkers / Linkers
Maleimide NHS Ester (SMCC)
Quick view. Maleimide NHS Ester (SMCC) is a heterobifunctional crosslinking intermediate identified by CAS 64987-85-5 and PubChem CID 125175. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 3 |
| Representative chemistry-platform program | del-zota |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
Maleimide NHS Ester (SMCC) is classified as conjugation linkers / linkers (Formula C16H18N2O6; molecular weight 334.32).
Maleimide NHS Ester (SMCC) — Reference use: amine-to-thiol conjugation studies using the NHS ester and maleimide reactive groups.
For Maleimide NHS Ester (SMCC), functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- SMCC
- Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
- N-Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
Useful catalog search terms
- Maleimide NHS Ester SMCC
- CAS 64987-85-5
- PubChem CID 125175
- JJAHTWIKCUJRDK-UHFFFAOYSA-N
Physicochemical data
| PubChem CID | 125175 |
|---|---|
| SMILES | C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CCC3=O |
| InChIKey | JJAHTWIKCUJRDK-UHFFFAOYSA-N |
| Product-form boundary | SMCC; distinct from Sulfo-SMCC |
| InChI | InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe Maleimide NHS Ester (SMCC) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Intermediates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.