Natural RNA / Phosphoramidites
DMTr-2'-O-TBDMS-rU-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-TBDMS-rU-3'-CE-Phosphoramidite is a 2'-O-TBDMS-protected uridine building block for research-use RNA oligonucleotide synthesis. CAS 118362-03-1. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | patisiran |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
DMTr-2'-O-TBDMS-rU-3'-CE-Phosphoramidite is classified as protected uridine phosphoramidite (Formula C45H61N4O9PSi; molecular weight 861.00).
DMTr-2'-O-TBDMS-rU-3'-CE-Phosphoramidite — 2'-O-TBDMS-protected uridine phosphoramidite building block for research-use RNA oligonucleotide synthesis.
For DMTr-2'-O-TBDMS-rU-3'-CE-Phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- rU Phosphoramidite
- 2'-TBDMS-U CEP
- DMT-2'-O-TBDMS-rU-3'-CE-Phosphoramidite
- 5'-DMT-2'-O-TBDMS-Uridine Phosphoramidite
Useful catalog search terms
- 118362-03-1
- PubChem 10898199
- C45H61N4O9PSi
- USP 1152042
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Ribose protection | 2'-O-TBDMS |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | SKNLXHRBXYGJOC-ZMHKPELYSA-N |
| InChI | InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(O)nc3=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite
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RNA (2'-O-TBDMS) Phosphoramidites · CAS: 147201-04-5
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RNA (2'-O-TBDMS) Phosphoramidites · CAS: 121058-88-6
Product-family literature
These publications provide peer-reviewed context for the RNA (2'-O-TBDMS) Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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