LNA / Phosphoramidites
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite is the 5'-O-DMTr, N6-benzoyl-protected LNA-adenosine 3'-cyanoethyl phosphoramidite identified by CAS 206055-79-0. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 2 |
| Representative chemistry-platform program | rugonersen |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Product profile
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite is classified as lna / phosphoramidites (Formula C48H52N7O8P; molecular weight 885.96).
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-A(Bz)-Phosphoramidite
- LNA-A(Bz)-CE Phosphoramidite
- 5'-DMTr-LNA-A(N-Bz) Phosphoramidite
Useful catalog search terms
- 206055-79-0
- HPIDKMAOZZZGOP-LIUGLABVSA-N
- PubChem CID 13009021
Physicochemical data
| Systematic name | (1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite |
|---|---|
| InChIKey | HPIDKMAOZZZGOP-LIUGLABVSA-N |
| Chemical form | 5'-O-DMTr, N6-benzoyl LNA-adenosine 3'-cyanoethyl phosphoramidite |
| PubChem CID | 13009021 |
| InChI | InChI=1S/C48H52N7O8P/c1-32(2)55(33(3)4)64(61-27-13-26-49)63-42-41-46(54-31-52-40-43(50-30-51-44(40)54)53-45(56)34-14-9-7-10-15-34)62-47(42,28-59-41)29-60-48(35-16-11-8-12-17-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,30-33,41-42,46H,13,27-29H2,1-6H3,(H,50,51,53,56)/t41-,42+,46-,47-,64?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H]2[C@@H](O[C@]1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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