2′-F / Phosphoramidites
DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite
Quick view. DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite is an L-DPSE-configured 2'-fluoro N2-isobutyryl guanosine building block for research-use stereodefined oligonucleotide synthesis. CAS 2227139-97-9. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 4 |
| Representative chemistry-platform program | WVE-N531 |
| Highest development phase | Phase III |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite is classified as l-dpse 2'-fluoro guanosine phosphoramidite (Formula C54H58FN6O8PSi; molecular weight 997.10).
DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite — L-DPSE-configured 2'-fluoro N2-isobutyryl guanosine phosphoramidite building block for research-use stereodefined oligonucleotide synthesis.
For DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite
- N2-Isobutyryl-5'-O-DMTr-2'-fluoro-dG-3'-(L)-DPSE-Phosphoramidite
Useful catalog search terms
- 2227139-97-9
- PubChem 178421319
- C54H58FN6O8PSi
- Synthgene PA247
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Sugar modification | 2'-fluoro |
| Phosphorus auxiliary | L-DPSE |
| InChIKey | GSSYTHNLCHZVRD-ABIOHNQMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: 1528734-00-0
OR-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: N/A
OR-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: N/A
OR-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: N/A
OR-2FP-0007DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: 2227140-01-2
OR-2FP-0008DMTr-2'-F-dG(iBu)-3'-(L)-PSM-Phosphoramidite
2'-Fluoro Phosphoramidites · CAS: N/A
Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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