2′-F / Phosphoramidites
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite is an N2-isobutyryl-protected 2'-fluoro-2'-deoxyguanosine building block for research-use oligonucleotide synthesis. CAS 144089-97-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 152.1 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite is classified as protected 2'-fluoro-2'-deoxyguanosine phosphoramidite (Formula C44H53FN7O8P; molecular weight 857.90).
DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite — N2-isobutyryl-protected 2'-fluoro-2'-deoxyguanosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dG(iBu) Phosphoramidite
- DMT-2'-F-dG(iBu)-CE Phosphoramidite
- N2-Isobutyryl-5'-O-DMTr-2'-fluoro-2'-deoxyguanosine-3'-CE Phosphoramidite
Useful catalog search terms
- 144089-97-4
- PubChem 135448972
- C44H53FN7O8P
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Sugar modification | 2'-fluoro-2'-deoxy |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | KJFUMXZZVYMQEU-AOCJBPQJSA-N |
| InChI | InChI=1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(60-61(58-24-12-23-46)52(28(3)4)29(5)6)35(59-42)25-57-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36-,38-,42-,61?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F |
| PubChem CID | 135448972 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-2FP-0007DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite
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Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.