2′-F / Phosphoramidites
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite is an N6-benzoyl-protected 2'-fluoro-2'-deoxyadenosine building block for research-use oligonucleotide synthesis. CAS 136834-22-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 7 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 463.2 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Related product programs
Product profile
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite is classified as protected 2'-fluoro-2'-deoxyadenosine phosphoramidite (Formula C47H51FN7O7P; molecular weight 875.90).
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite — N6-benzoyl-protected 2'-fluoro-2'-deoxyadenosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dA(Bz) Phosphoramidite
- DMT-2'-F-dA(Bz)-CE Phosphoramidite
- N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxyadenosine-3'-CE Phosphoramidite
Useful catalog search terms
- 136834-22-5
- PubChem 12042896
- C47H51FN7O7P
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| Sugar modification | 2'-fluoro-2'-deoxy |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | VCCMVPDSLHFCBB-MSIRFHFKSA-N |
| InChI | InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
| PubChem CID | 12042896 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.