2′-OMe / Nucleoside Intermediates
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU
Quick view. A uridine analog bearing a 2'-O-methyl group, a free 3'-hydroxyl group and an E-vinyl phosphonate bis(POM) ester at the 5' side. CAS 2172373-51-0. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | mivelsiran |
| Highest development phase | Phase II |
| CAS status | Published registry number |
Product profile
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU is classified as 2′-ome / nucleoside intermediates (Formula C23H35N2O12P; molecular weight 562.51).
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- POM-(E)-vinyl phosphonate-2'-O-Me-rU
- 5'-POM-vinyl phosphonate, 2'-OMe-U
- 5'-(E)-VP-2'-OMe-U
Useful catalog search terms
- 2172373-51-0
- IQVFHCHMSAXIBF-QSEATPFUSA-N
Physicochemical data
| InChIKey | IQVFHCHMSAXIBF-QSEATPFUSA-N |
|---|---|
| Nucleobase | Uracil |
| Sugar modification | 2'-O-methyl with free 3'-hydroxyl |
| 5' modification | E-vinyl phosphonate bis(POM) ester |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
Product-family literature
These publications provide peer-reviewed context for the Other Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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