N3′→P5′ Thiophosphoramidate / Phosphoramidites
3'-NH-Trt-2',3'-ddA(Bz)-5'-CE-Phosphoramidite
Quick view. A protected 3'-amino-2',3'-dideoxyadenosine building block bearing N6-benzoyl and 3'-N-trityl protection with a 5'-O-CE diisopropylphosphoramidite group. CAS 195375-64-5. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 1 |
| Representative chemistry-platform program | imetelstat |
| Planning-model annual demand | 18.9 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
3'-NH-Trt-2',3'-ddA(Bz)-5'-CE-Phosphoramidite is classified as n3′→p5′ thiophosphoramidate / phosphoramidites (Formula C45H49N8O4P; molecular weight 796.90).
3'-NH-Trt-2',3'-ddA(Bz)-5'-CE-Phosphoramidite is supplied for research use within the Imetelstat Series Phosphoramidites product family.
For 3'-NH-Trt-2',3'-ddA(Bz)-5'-CE-Phosphoramidite, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- ((2S,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(tritylamino)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite
Useful catalog search terms
- CAS 195375-64-5
Physicochemical data
| Protection pattern | N6-benzoyl; 3'-N-trityl; 5'-O-CE diisopropylphosphoramidite |
|---|---|
| Sugar stereochemistry | (2S,3S,5R) in the PubChem title representation |
| Phosphorus stereochemistry | Unspecified |
| InChIKey | WFMJBNBVXHQESI-YWGGCHKGSA-N |
| PubChem CID | 10557285 |
| InChI | InChI=1S/C45H49N8O4P/c1-32(2)53(33(3)4)58(55-27-17-26-46)56-29-39-38(51-45(35-20-11-6-12-21-35,36-22-13-7-14-23-36)37-24-15-8-16-25-37)28-40(57-39)52-31-49-41-42(47-30-48-43(41)52)50-44(54)34-18-9-5-10-19-34/h5-16,18-25,30-33,38-40,51H,17,27-29H2,1-4H3,(H,47,48,50,54)/t38-,39+,40+,58?/m0/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H](C[C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)NC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
3'-NH-Trt-2',3'-ddA(dmf)-5'-CE-Phosphoramidite
Imetelstat Series Phosphoramidites · CAS: 1644649-86-4
OR-ISP-00023'-NH-Trt-2',3'-ddC(Bz)-5'-CE-Phosphoramidite
Imetelstat Series Phosphoramidites · CAS: 195375-65-6
OR-ISP-00033'-NH-Trt-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
Imetelstat Series Phosphoramidites · CAS: 195375-66-7
OR-ISP-00043'-NH-Trt-2',3'-ddT-5'-CE-Phosphoramidite
Imetelstat Series Phosphoramidites · CAS: 195375-68-9
Product-family literature
These publications provide peer-reviewed context for the Imetelstat Series Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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