2′-OMe / Succinates
DMTr-2'-OMe-G(iBu)-3'-Succinate
Quick view. DMTr-2'-OMe-G(iBu)-3'-Succinate is a protected 2'-O-methylguanosine derivative bearing 5'-O-DMTr, N2-isobutyryl, and 3'-O-succinate groups in the free-acid form. The reviewed identity corresponds to PubChem CID 138376007. CAS 114745-31-2. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Priority |
| Development context | ↑ Upstream — reviewed as a supporting input; no direct development phase is assigned |
| CAS status | Published registry number |
Product profile
DMTr-2'-OMe-G(iBu)-3'-Succinate is classified as protected 2'-o-methylguanosine 3'-o-succinate (Formula C40H43N5O11; molecular weight 769.80).
DMTr-2'-OMe-G(iBu)-3'-Succinate supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For DMTr-2'-OMe-G(iBu)-3'-Succinate, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyl-N2-isobutyrylguanosine-3'-succinate
Useful catalog search terms
- CAS 114745-31-2
- Succinates
Physicochemical data
| PubChem CID | 138376007 |
|---|---|
| InChIKey | UPTKBAGZMOVVLJ-POQUMROWSA-N |
| Structural features | 5'-O-DMTr; 2'-O-methyl; N2-isobutyryl guanine; 3'-O-succinate; free carboxylic acid |
| InChI | InChI=1S/C40H43N5O11/c1-23(2)36(49)43-39-42-35-32(37(50)44-39)41-22-45(35)38-34(53-5)33(56-31(48)20-19-30(46)47)29(55-38)21-54-40(24-9-7-6-8-10-24,25-11-15-27(51-3)16-12-25)26-13-17-28(52-4)18-14-26/h6-18,22-23,29,33-34,38H,19-21H2,1-5H3,(H,46,47)(H2,42,43,44,49,50)/t29-,33-,34-,38-/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-OMe-G(iBu)-3'-Succinate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-SUCC-0024DMTr-2'-MOE-G(iBu)-3'-Succinate
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Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.