2′-F / Nucleoside Intermediates
2'-Fluoro-2'-deoxyuridine
Quick view. 2'-Fluoro-2'-deoxyuridine is a ribo-configured 2'-fluoro nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 784-71-4. Catalog target purity: Specification by inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Catalog status
Scope. "Available for inquiry" is not a stock claim. Operating tier is a catalog-merchandising priority. Development phase and program context are shown only where the reviewed catalog source provides a mapping; they describe the chemistry platform and do not claim that OROGO supplies the named program. Annual demand is a planning-model estimate from the reviewed demand dataset, not OROGO sales, inventory, a guaranteed market size or a supply commitment.
| Supply status | Available for inquiry |
|---|---|
| Operating tier | Core |
| Reviewed supporting program count | 6 |
| Representative chemistry-platform program | fitusiran |
| Planning-model annual demand | 3.8 kg/year |
| Demand estimate basis | Planning model: current marketed plus clinical-stage programs |
| Highest development phase | Marketed |
| CAS status | Published registry number |
Product profile
2'-Fluoro-2'-deoxyuridine is classified as 2'-fluoro nucleoside (Formula C9H11FN2O5; molecular weight 246.19).
A 2'-fluoro-2'-deoxyuridine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-Fluoro-2'-deoxyuridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dU
- 2'-Deoxy-2'-fluoro-D-uridine
- Uridine, 2'-deoxy-2'-fluoro-
Useful catalog search terms
- CAS 784-71-4
Physicochemical data
| PubChem CID | 150851 |
|---|---|
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
| Modification | fluorine at the ribose 2'-position |
| InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1 |
| SMILES | C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Fluoro-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.